Slovak biotech company Axon Neuroscience announced positive pre-clinical results of coronavirus vaccine

By bne IntelliNews September 16, 2020

Slovak clinical-stage biotech company Axon Neuroscience has reported positive pre-clinical results of its vaccine against the coronavirus (COVID-19), tested on mice with no adverse side effects, the company reported in a press release.

According to the company, mice vaccinated with a vaccine generated a high titer of antibodies in blood which selectively targeted a specific, vulnerable part of the Spike protein that allows the virus to infect the cells and replicate.

“We identified the weakest points of the SARS-CoV-2 virus and instructed the immune system to target these small areas of up to 20 amino acids in order to completely eliminate the viral infection. The data from the virus neutralisation test showed that our strategy was successful,” said MVD, DSc, chief science officer at Axon Norbert Zilka.

The raised antibodies in blood efficiently neutralised the live COVID-19 virus. The vaccinated mice did not show any signs of off-target effects or adverse reactions. 

“ACvac1 very precisely instructs the immune system to neutralise the virus. In contrast, other vaccine candidates overwhelm the immune system by producing numerous ineffective antibodies by introducing a 1200-amino-acids-long Spike protein as an antigen,” Zilka added.  

“With today’s positive results, our peptide-based vaccination platform has proven its potential use for COVID-19. We are progressing toward clinical trials to bring the world a vaccine without compromising safety and efficacy. This work is based on more than 10 years of experience in developing exceptionally safe and immunogenic peptide vaccines for neurodegenerative disorders.” commented Axon’s chief executive officer Michal Fresser, adding that the company will soon start testing on people. 

 
 

Related Articles

Slovak biotech company Axon Neuroscience creates antibodies to stop COVID-19 from reproducing

Slovak clinical-stage biotech company Axon Neuroscience has created therapeutic antibodies able to prevent reproduction of the coronavirus (COVID-19), with the efficacy of these antibodies ... more

Volkswagen to invest €1bn to create 2,000 new jobs in Slovakia

The Volkswagen plant in Bratislava plans to create 2,000 new jobs via a planned investment of €1bn, said VW Slovakia's personnel director Sebastian Krapoth at a press conference on November 16. ... ... more

State of emergency in Slovakia to be extended to year-end

The Slovak government has decided to extend the state of emergency by 45 days from November 14 until the end of the year, due to the development of the coronavirus (COVID-19) situation in the ... more

Dismiss